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- Title
High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies.
- Authors
Yasuhito Hamaguchi; Takashi Matsushita; Minoru Hasegawa; Ikuko Ueda-Hayakawa; Sinichi Sato; Kazuhiko Takehara; Manabu Fujimoto
- Abstract
Systemic sclerosis (SSc)-related autoantibodies are useful tools in identifying clinically homogenous subsets of patients and predicting their prognosis. In this report, we described five SSc patients with anti-centriole antibodies. All five patients were females and had digital ulcers/gangrene. Four of five (80%) patients had pulmonary arterial hypertension (PAH). None of the five patients had active pulmonary fibrosis or developed renal crisis. Anti-centriole antibodies may be a marker for PAH and digital ulcers/gangrene.
- Subjects
PULMONARY arterial hypertension; SYSTEMIC scleroderma; PROGNOSIS; AUTOANTIBODIES; PULMONARY fibrosis
- Publication
Modern Rheumatology, 2015, Vol 25, Issue 5, p798
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/14397595.2013.844296