We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Galla Chinensis Attenuates Cigarette Smoke-associated Lung Injury by Inhibiting Recruitment of Inflammatory Cells into the Lung.
- Authors
Lee, Hyojung; Yu, Seung‐Ryeol; Lim, Dahae; Lee, Hyejung; Jin, Eun‐Young; Jang, Young‐Pyo; Kim, Jinju
- Abstract
Inflammation is a common feature in the pathogenesis of cigarette smoke (CS)-associated diseases. In this study, we investigated the effects of Galla Chinensis (GC) extract on pulmonary inflammatory responses in a CS-exposed mouse model. In vitro studies showed that GC extract reduced MCP-1 production in a dose-dependent manner. In addition, the recruitment of inflammatory cells into the lung was significantly inhibited in the bronchoalveolar lavage fluid (BALF) of the GC-treated mice after 3 weeks of daily CS exposure. GC treatment down-regulated TNF-α, IL-6 and MCP-1 mRNA expression levels in lung tissue. Finally, GC-treated mice showed less emphysematous change of alveolar compared to mice only exposed to CS. Our results show that GC extract reduces lung inflammation and emphysematous change by inhibiting the infiltration of inflammatory cells to the lung. These data indicate that GC extract is a therapeutic candidate for CS-induced lung injury.
- Subjects
ANACARDIACEAE; THERAPEUTIC use of plant extracts; PHYSIOLOGICAL effects of tobacco; LUNG disease treatment; MONOCYTE chemotactic factor; LABORATORY mice
- Publication
Basic & Clinical Pharmacology & Toxicology, 2015, Vol 116, Issue 3, p222
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12308