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- Title
Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines.
- Authors
Zhang, Naru; Li, Chaoqun; Jiang, Shibo; Du, Lanying
- Abstract
Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV). They have expanded in geographic distribution and refocused international attention in recent years. Vaccination is one of the most effective public health strategies for combating flavivirus infections. In this review, we summarized virus-like particle (VLP)-based vaccines against the above four mentioned flaviviruses. Potential strategies to improve the efficacy of VLP-based flavivirus vaccines were also illustrated. The applications of flavivirus VLPs as tools for viral detection and antiviral drug screening were finally proposed.
- Subjects
JAPANESE encephalitis viruses; WEST Nile virus; DENGUE viruses; ZIKA virus; FLAVIVIRAL diseases
- Publication
Vaccines, 2020, Vol 8, Issue 3, p481
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines8030481