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- Title
From Womb to Brain: Unravelling Neuro-Enhancement Effect of Centella asiatica on Transdifferentiation of Full-Term Amniotic Fluid Stem Cells into Neural Stem Cells.
- Authors
Rahman, Khairul Akmal Abdul; Khor, Winnie; Hwa Ling, King; Tohid, Siti Farah Md; Nordin, Norshariza
- Abstract
An efficient protocol that could enhance the generation of quality non-brain-sourced neural stem cells (NSCs) for the treatment of neurodegenerative diseases (ND) is essential. This study aims to evaluate the effect of Centella asiatica (CA), which has been consumed traditionally as memory tonic, in enhancing the transdifferentiation potential of full-term amniotic fluid stem cells (AFSCs), a highly neurogenic stem cell, into NSCs. Treatment with CA extract was found to increase the expression of NSC protein markers, generate more good quality neurospheres and enhance the expression of selected neuronal markers. These findings strongly suggest that CA has the potential to enhance NSCs transdifferentiated from AFSCs, demonstrating the remarkable ability of non-brain-sourced stem cells derived from merely discarded fluid to transform into brain cells.
- Subjects
NEURAL stem cells; CENTELLA asiatica; AMNIOTIC liquid; STEM cells; UTERUS
- Publication
Malaysian Journal of Medicine & Health Sciences, 2023, Vol 19, p21
- ISSN
1675-8544
- Publication type
Article