We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response.
- Authors
Imran, Siti A. M.; Yazid, Muhammad Dain; Wei Cui; Lokanathan, Yogeswaran
- Abstract
Introduction: Telomere repeat binding factor 2 (TRF2) has a well-known function at the telomeres, protecting the telomere ends from being recognized as a DNA break or from unwanted recombination. This protection mechanism prevents DNA instability from mutation and subsequent severe diseases caused by the changes in DNA, such as cancer. Since TRF2 actively inhibits the DNA damage response factors from recognizing the telomere end as a DNA break, many more studies have also shown its interactions outside of the telomeres. However, very little has been discovered on the mechanisms involved in these interactions. Methods: A scoping review of available literature that reported on the interaction of TRF2 with the DNA Damage Response (DDR) factors or its role in DDR was conducted. Results: It has been well established that TRF2 actively inhibits the DDR through the ATM kinase pathway at the telomeres. However, recent findings have also reported the role of TRF2 with the DDR outside of the telomeres. It has also been reported that TRF2 may be an early response factor to extra-telomeric DNA damage. These actions may be attributed to TRF2 post-translational modification or recruitment by other DDR factors. Previous findings on its colocalization at the DNA damage site and other DDR factors outside the telomeric regions have shed light on its more extensive role in regulating and maintaining DNA stability and its clinical implications. Conclusion: As discussed in this review, some extra-telomeric interactions of TRF2 with DDR factors have been established. However, very few mechanisms of such interactions have been determined and explored. The investigation of the molecular mechanism in the possible interaction between TRF2 and other DDR factors, either directly or indirectly, is needed to confirm whether there is a specific role TRF2 plays in DNA damage repair if any exists.
- Subjects
DNA damage; DNA repair; POST-translational modification; TELOMERES; PROTHROMBIN
- Publication
Malaysian Journal of Medicine & Health Sciences, 2022, Vol 18, p5
- ISSN
1675-8544
- Publication type
Abstract