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- Title
High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults.
- Authors
Jieli Lu; Sin Man Lam; Qin Wan; Lixin Shi; Yanan Huo; Lulu Chen; Xulei Tang; Bowen Li; Xueyan Wu; Kui Peng; Mian Li; Shuangyuan Wang; Yu Xu; Min Xu; Yufang Bi; Guang Ning; Guanghou Shui; Weiqing Wang; Lu, Jieli; Lam, Sin Man
- Abstract
<bold>Objective: </bold>Comprehensive assessment of serum lipidomic aberrations before type 2 diabetes mellitus (T2DM) onset has remained lacking in Han Chinese. We evaluated changes in lipid coregulation antecedent to T2DM and identified novel lipid predictors for T2DM in individuals with normal glucose regulation (NGR).<bold>Research Design and Methods: </bold>In the discovery study, we tested 667 baseline serum lipids in subjects with incident diabetes and propensity score-matched control subjects (n = 200) from a prospective cohort comprising 3,821 Chinese adults with NGR. In the validation study, we tested 250 lipids in subjects with incident diabetes and matched control subjects (n = 724) from a pooled validation cohort of 14,651 individuals with NGR covering five geographical regions across China. Differential correlation network analyses revealed perturbed lipid coregulation antecedent to diabetes. The predictive value of a serum lipid panel independent of serum triglycerides and 2-h postload glucose was also evaluated.<bold>Results: </bold>At the level of false-discovery rate <0.05, 38 lipids, including triacylglycerols (TAGs), lyso-phosphatidylinositols, phosphatidylcholines, polyunsaturated fatty acid (PUFA)-plasmalogen phosphatidylethanolamines (PUFA-PEps), and cholesteryl esters, were significantly associated with T2DM risk in the discovery and validation cohorts. A preliminary study found most of the lipid predictors were also significantly associated with the risk of prediabetes. Differential correlation network analysis revealed that perturbations in intraclass (i.e., non-PUFA-TAG and PUFA-TAGs) and interclass (i.e., TAGs and PUFA-PEps) lipid coregulation preexisted before diabetes onset. Our lipid panel further improved prediction of incident diabetes over conventional clinical indices.<bold>Conclusions: </bold>These findings revealed novel changes in lipid coregulation existing before diabetes onset and expanded the current panel of serum lipid predictors for T2DM in normoglycemic Chinese individuals.
- Subjects
CHINA; BLOOD lipids; TYPE 2 diabetes; LIPIDS; UNSATURATED fatty acids
- Publication
Diabetes Care, 2019, Vol 42, Issue 11, p2117
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc19-0100