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- Title
Metabolite Identification by Mass Spectrometry.
- Authors
Shah, Priya V.; Shah, Jaivik V.; Saroj, Seema D.; Jairaj, Vinod; Rathod, Rajeshwaree
- Abstract
Study of fate of metabolites is important in early stage of drug discovery and development, as this metabolite may be toxic or pharmacologically active. Mass spectrometry plays a key role in drug metabolite identification. High resolution mass spectrometry (HRMS) with new data processing techniques has improved the quality of metabolite identification process. In this review the approaches of mass spectroscopy in metabolite identification are reviewed. It also discusses traditional and modern liquid chromatography-mass spectrometry (LC-MS) approaches including in silico tool, tandem mass spectroscopy (MSn), and HRMS for Metabolite identification. General steps that are to be followed for metabolite identification by HRMS are also summarised.
- Subjects
METABOLITES; MASS spectrometry; LIQUID chromatography-mass spectrometry; SILICON; BIOMOLECULES
- Publication
International Journal of Pharmaceutical Research & Allied Sciences, 2015, Vol 4, Issue 4, p9
- ISSN
2277-3657
- Publication type
Article