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- Title
Synthesis and Antitubercular Evaluation of Diverse Glycosylated Ureas from D-Glucose.
- Authors
Tripathi, Neetu; Tiwari, Vinod K.
- Abstract
N, N-disubstituted glycosylated ureas have been synthesized in good-to-excellent yields by 1,4-conjugate addition of amines to glycosylated olefinic esters followed by reaction of resulting glycosyl β-amino esters with diisocyanates. The developed sugar-based molecules were well characterized by extensive standard spectroscopic analysis including NMR (1H, 13C, and DEPT), IR, MS, and elemental analysis and were screened for their biological activity against Mycobacterium tuberculosis (M. Tb.), where some of them displayed potent antitubercular activity. The molecules have been designed keeping in view the well-known inhibitors of the enzymes involved in the biosynthesis of mycobacterial cell wall polymers and may be further explored as lead molecules for the successful development of a potential antitubercular drug candidate. Dedicated to Dr. Rama P. Tripathi, Former Chief Scientist at CSIR-Central Drug Research Institute, Lucknow, India, for his extraordinary contribution to "Drug development against Tuberculosis"
- Subjects
LUCKNOW (India); MYCOBACTERIUM tuberculosis; ANTITUBERCULAR agents; UREA; ENZYME inhibitors; DRUG development; CONJUGATED polymers; GLYCOSYLATED hemoglobin
- Publication
Journal of Chemistry, 2024, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2024/8709672