We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Taste Bud Leptin: Sweet Dampened at Initiation Site.
- Authors
Travers, Susan P.; Frank, Marion E.
- Abstract
The intriguing observation that leptin decreases sweet-evoked peripheral gustatory responses has aroused much interest (Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y. 2000. Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci U S A. 97(20):11044-11049.) due to its implied importance in controlling appetite. The effects of this anorexic hormone, however, appear more conditional than originally believed. In this issue of Chemical Senses, a careful study by Glendinning and colleagues, find no effects of leptin on sweet-evoked chorda tympani responses, whereas an equally careful study by Meredith and colleagues, find decreased release of ATP and increased release of 5-HT from taste buds in response to sweet stimuli.
- Subjects
TASTE buds; LEPTIN; APPETITE; TYMPANIC membrane; LABORATORY mice
- Publication
Chemical Senses, 2015, Vol 40, Issue 4, p213
- ISSN
0379-864X
- Publication type
Opinion
- DOI
10.1093/chemse/bjv004