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- Title
Phenylthiocarbamide Produces Conditioned Taste Aversions in Mice.
- Authors
St. John, Steven J.; Pour, Lindsay; Boughter, John D.
- Abstract
Previous work has demonstrated that SWR/J (SW) mice avoid phenylthiocarbamide (PTC) to a greater degree than C3HeB/FeJ mice in 48 h, two-bottle preference tests given in ascending series. The authors hypothesized, based also on previous work, that SW mice might form a conditioned taste aversion over time due to the toxic properties of PTC. We directly tested this hypothesis by attempting to condition a taste aversion to sucrose by injections of PTC. In experiment 1, PTC was nearly as effective as a strong dose of LiCl in reducing sucrose drinking. In experiment 2, the sucrose aversions were parametrically modified by both sucrose concentration and PTC dose, a hallmark of conditioned taste aversion. We conclude that PTC can cause a conditioned taste aversion and discuss the importance of considering toxic effects of aversive tastants when analyzing behavioral strain differences.
- Subjects
TASTE aversion; LABORATORY mice; SUCROSE; TOXICOLOGY; BITTERNESS (Taste)
- Publication
Chemical Senses, 2005, Vol 30, Issue 5, p377
- ISSN
0379-864X
- Publication type
Article
- DOI
10.1093/chemse/bji032