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- Title
(2I) Cytokine mRNA in psoriatic skin detected by in situ hybridization.
- Authors
Colver, G. B.; Dickens, E. M.; Wood, N. C.; Duff, G. W.
- Abstract
This article presents a study which states that cytokine mRNA in psoriatic skin detected by in situ hybridization. The cytokines interleukin 1 (IL1) and tumour necrosis factor (TNF) have been implicated in the pathogenesis of infiammatory and immune diseases. Resident skin cells as well as infiltrating mononuclear cells, can all produce IL1 when activated in vitro. IL1 peptides have been identified in extracts of human psoriatic skin and also in suctionblister fluid. Results showed cells containing IL1 beta mRNA in both the epidermis and dermis of psoriatic lesions.
- Subjects
MESSENGER RNA; CYTOKINES; INTERLEUKIN-1; IMMUNOREGULATION; TUMOR necrosis factors; IMMUNOLOGIC diseases
- Publication
British Journal of Dermatology, 1988, Vol 119, p54
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1988.tb05395.x