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- Title
Mechanistic Chemistry of Extraordinary Capacity of Salvianolic Acid B on Oxidatively-damaged Mesenchymal Stem Cells.
- Authors
Wang, Tingting; Li, Xican; Li, Yunrong; Wu, Jianrun; Huang, Yuyin; Wei, Gang; Chen, Dongfeng
- Abstract
As the main bioactive component of Chinese herbal medicine Danshen, salvianolic acid B (Sal B, or lithospermic acid B) was observed to maintain the viability of mesenchymal stem cells ( MSCs) treated by Fenton's reagent in the study. Interestingly, at a higher concentration, Sal B could even increase the viability rate to 175.1%. In mechanistic analysis experiments, Sal B was found to resist DNA destruction by • OH radical, scavenge various radicals in vitro, reduce Cu2+ → Cu+, chelate Fe2+ to yield an absorption maximum at 710 nm. Based on these results, we concluded that, (1) Sal B can not only protect MSCs against • OH-induced damages, but also promote their proliferation. This extraordinary capacity makes Sal B an ideal candidate in MSCs transplantation especially when MSCs are polluted by iron-overload or other oxidative stress factors and, can partly be responsible for the versatile properties of Sal B in pharmacology. The possible mechanisms of its protective effect are hypothesized to include Fe2+ chelating, and direct radical scavenging which is involved in electron transfer ( ET) or hydrogen atom transfer ( HAT) from the catechol moieties. Its proliferation-promoting effect is presumed to be from its ester group, carboxylic group, or benzofuran ring.
- Subjects
CHINA; MESENCHYMAL stem cells; HERBAL medicine; PHYTOCHEMICALS; MEDICINAL plants; MECHANICAL chemistry; PHYSIOLOGY
- Publication
Journal of the Chinese Chemical Society, 2016, Vol 63, Issue 11, p924
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201600112