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- Title
What Syndrome Is This?
- Authors
Costa, Teresa; Eichenfield, Lawrence F.; Krafchik, Bernice R.
- Abstract
The article presents the case history and pictures related to Costello syndrome. The patients develop redundant skin on the palms, soles, fingers, and nape of the neck associated with deep palmar and plantar creases. Many of the older children have papillomata around the nares and scattered on other areas of the body. All the reported children had mild to moderate mental retardation. Growth parameters at birth were normal, but short stature was a constant feature in later childhood. One of the major problems in infants with Costello syndrome is the inability to suck, although when tested, esophageal motility is normal. The cause and pathogenesis of Costello syndrome is unknown. Metabolic studies to date have been negative with the exception of a recent report of high levels of sialic acid in the urine.
- Subjects
SYNDROMES; SKIN diseases; SHORT stature; INTELLECTUAL disabilities; SIALIC acids; PATHOLOGY
- Publication
Pediatric Dermatology, 1994, Vol 11, Issue 3, p277
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/j.1525-1470.1994.tb00604.x