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- Title
hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
- Authors
Okasaka, Toshiki; Matsuo, Keitaro; Suzuki, Takeshi; Ito, Hidemi; Hosono, Satoyo; Kawase, Takakazu; Watanabe, Miki; Yatabe, Yasushi; Hida, Toyoaki; Mitsudomi, Tetsuya; Tanaka, Hideo; Yokoi, Kohei; Tajima, Kazuo
- Abstract
Human 8-oxoguanine DNA glycosylase 1 (hOGG1) has a major role in the repair of 8-hydroxyguanine, a major promutagenic DNA lesion. The genetic polymorphism rs1052133, which leads to substitution of the amino acid at codon 326 from Ser to Cys, shows functional differences, namely a decrease in enzyme activity in hOGG1-Cys326. Although several studies have investigated the association between rs1052133 and lung cancer susceptibility, the effect of this locus on lung cancer according to histology remains unclear. We therefore conducted a case–control study with 515 incident lung cancer cases and 1030 age- and sex-matched controls without cancer, and further conducted a meta-analysis. In overall analysis, the homozygous Cys/Cys genotype showed a significant association with lung cancer compared to Ser allele carrier status (odds ratio (OR)=1.31, 95% confidence interval (CI)=1.02–1.69). By histology-based analysis, the Cys/Cys genotype showed a significantly positive association with small-cell carcinoma (OR=2.40, 95% CI=1.32–4.49) and marginally significant association with adenocarcinoma (OR=1.32, 95% CI=0.98–1.77). A meta-analysis of previous and our present study revealed that this polymorphism is positively associated with adenocarcinoma, although suggestive associations were also found for squamous- and small-cell lung cancers. These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung.
- Subjects
GENETIC polymorphisms; LUNG cancer; AMINO acids; HISTOLOGY; META-analysis; ADENOCARCINOMA
- Publication
Journal of Human Genetics, 2009, Vol 54, Issue 12, p739
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1038/jhg.2009.108