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- Title
Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1).
- Authors
Seki, Naohiko; Muramatsu, Masa-aki; Sugano, Sumio; Suzuki, Yutaka; Nakagawara, Akira; Ohhira, M.; Hayashi, Akiko; Hori, Tada-aki; Saito, T.
- Abstract
Abstract Huntington disease (HD) is an inherited neurodegenerative disorder which is associated with CAG expansion in the coding region of the gene for huntingtin protein. Recently, a huntingtin interacting protein, HIP1, was isolated by the yeast two-hybrid system. Here we report the isolation of a cDNA clone for HIP1R (huntingtin interacting protein-1 related), which encodes a predicted protein product sharing a striking homology with HIP1. RT-PCR analysis showed that the messenger RNA was ubiquitously expressed in various human tissues. Based on PCR-assisted analysis of a radiation hybrid panel and fluorescence in situ hybridization, IIIPIR was localized to the q24 region of chromosome 12.
- Subjects
HUNTINGTON disease; PROTEINS; CLONING; CHROMOSOMES
- Publication
Journal of Human Genetics, 1998, Vol 43, Issue 4, p268
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380050087