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- Title
Carbapenem-Nonsusceptible Acinetobacter baumannii, 8 US Metropolitan Areas, 2012-2015.
- Authors
Bulens, Sandra N.; Yi, Sarah H.; Walters, Maroya S.; Jacob, Jesse T.; Bower, Chris; Reno, Jessica; Wilson, Lucy; Vaeth, Elisabeth; Bamberg, Wendy; Janelle, Sarah J.; Lynfield, Ruth; Vagnone, Paula Snippes; Shaw, Kristin; Kainer, Marion; Muleta, Daniel; Mounsey, Jacqueline; Dumyati, Ghinwa; Concannon, Cathleen; Beldavs, Zintars; Cassidy, P. Maureen
- Abstract
In healthcare settings, Acinetobacter spp. bacteria commonly demonstrate antimicrobial resistance, making them a major treatment challenge. Nearly half of Acinetobacter organisms from clinical cultures in the United States are nonsusceptible to carbapenem antimicrobial drugs. During 2012-2015, we conducted laboratory- and population-based surveillance in selected metropolitan areas in Colorado, Georgia, Maryland, Minnesota, New Mexico, New York, Oregon, and Tennessee to determine the incidence of carbapenem-nonsusceptible A. baumannii cultured from urine or normally sterile sites and to describe the demographic and clinical characteristics of patients and cases. We identified 621 cases in 537 patients; crude annual incidence was 1.2 cases/100,000 persons. Among 598 cases for which complete data were available, 528 (88.3%) occurred among patients with exposure to a healthcare facility during the preceding year; 506 (84.6%) patients had an indwelling device. Although incidence was lower than for other healthcare-associated pathogens, cases were associated with substantial illness and death.
- Subjects
UNITED States; CARBAPENEMS; ACINETOBACTER baumannii; ANTI-infective agents; DRUG resistance; PATHOGENIC microorganisms; ACINETOBACTER infections; COMPARATIVE studies; DRUG resistance in microorganisms; HISTORY; RESEARCH methodology; MEDICAL cooperation; PUBLIC health surveillance; RESEARCH; EVALUATION research; DISEASE incidence; GRAM-negative aerobic bacteria; PHARMACODYNAMICS
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 4, p727
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2404.171461