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- Title
Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis.
- Authors
Maryandyshev, Andrey; Pontali, Emanuele; Tiberi, Simon; Akkerman, Onno; Ganatra, Shashank; Sadutshang, Tsetan Dorji; Alffenaar, Jan-Willem; Amale, Rohit; Mullerpattan, Jai; Topgyal, Sonam; Udwadia, Zarir Farokh; Centis, Rosella; D'Ambrosio, Lia; Sotgiu, Giovanni; Battista Migliori, Giovanni; Migliori, Giovanni Battista
- Abstract
We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.
- Subjects
DRUG therapy for tuberculosis; DRUG resistance in microorganisms; ANTITUBERCULAR agents; TUBERCULOSIS treatment; TUBERCULOSIS; TUBERCULOSIS microbiology; COMBINATION drug therapy; HETEROCYCLIC compounds; IMIDAZOLES; QUINOLINE; THERAPEUTICS
- Publication
Emerging Infectious Diseases, 2017, Vol 23, Issue 10, p1718
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2310.170834