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- Title
Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection.
- Authors
Hingley-Wilson, Suzanne M.; Casey, Rosalyn; Connell, David; Bremang, Samuel; Evans, Jason T.; Hawkey, Peter M.; Smith, Grace E.; Jepson, Annette; Philip, Stuart; Onn Min Kon; Lalvani, Ajit
- Abstract
Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.
- Subjects
MULTIDRUG-resistant tuberculosis; DRUG resistance in microorganisms; THERAPEUTICS; MIXED infections; INFECTION; MYCOBACTERIUM tuberculosis
- Publication
Emerging Infectious Diseases, 2013, Vol 19, Issue 7, p1138
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1907.130313