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- Title
A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation.
- Authors
Pan, Q.; Zhu, Y.-J.; Gu, B.-W.; Cai, X.; Bai, X.-T.; Yun, H.-Y.; Zhu, J.; Chen, B.; Weng, L.; Chen, Z.; Xue, Y.-Q.; Chen, S.-J.
- Abstract
NUP98 has been involved in multiple recurrent chromosome rearrangements in leukemia. We identified a novel fusion between NUP98 and IQ motif containing G (IQCG) gene from a de novo acute T-lymphoid/myeloid leukemia harboring t(3;11)(q29q13;p15)del(3)(q29). IQCG has two putative coiled-coil domains and one IQ domain. The FG repeat from NUP98 and the coiled-coil domain from IQCG were retained in the fusion protein. We demonstrated that NUP98-IQCG could form homodimer, heterodimerize with NUP98 or IQCG, bind co-activators and/or co-repressors, and show transcriptional activity in vitro. Expression of NUP98-IQCG inhibited 32Dcl3 cell apoptosis induced by Ara-C, and partially blocked granulocyte differentiation induced by G-CSF. Colony-forming assay and serial replating assays indicated that NUP98-IQCG was able to stimulate proliferation, partially block differentiation of hematopoietic stem/progenitor cells but was unable to confer transformation alone. Taken together, our data indicate that newly identified NUP98-IQCG fusion protein may play an essential role in leukemogenesis, but by itself may not be sufficient to induce leukemia.Oncogene (2008) 27, 3414–3423; doi:10.1038/sj.onc.1210999; published online 17 December 2007
- Subjects
GENE fusion; MYELOID leukemia; CHROMOSOMAL translocation; PRELEUKEMIA; APOPTOSIS; LEUCOCYTOSIS; ANEMIA; LEUKEMIA etiology
- Publication
Oncogene, 2008, Vol 27, Issue 24, p3414
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1210999