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- Title
Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism.
- Authors
Wu, Guo-Dong; Pan, An; Zhang, Xu; Cai, Yuan-Yuan; Wang, Qi; Huang, Feng-Qing; Alolga, Raphael N.; Li, Jing; Qi, Lian-Wen; Liu, Qun
- Abstract
Abstract: Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis of obesity. Cordyceps comprises the larval body and the stroma of Cordyceps sinensis (BerK.) Sacc. parasiting on Hepialidae larvae of moths (H. pialusoberthur) with potent metabolic regulation functions. The underlying anti-obesity mechanisms, however, remain largely unknown. Here, we demonstrate that the water extract of Cordyceps attenuates glucose and lipid metabolism disorders and its associated inflammation in high-fat diet (HFD)-fed mice. 16S rRNA gene sequencing and microbiomic analysis showed that Cordyceps reduced the amounts of Enterococcus cecorum, a bile-salt hydrolase-producing microbe to regulate the metabolism of bile acids in the gut. Importantly, E. cecorum transplantation or liver-specific knockdown of farnesoid X receptor (FXR), a bile acid receptor, diminished the protective effect of Cordyceps against HFD-induced obesity. Together, our results shed light on the mechanisms that underlie the glucose- and lipid-lowering effects of Cordyceps and suggest that targeting intestinalE. cecorum or hepatic FXR are potential anti-obesity and anti-inflammation therapeutic avenues.
- Subjects
CHINA; OBESITY treatment; IN vitro studies; LIPOPOLYSACCHARIDES; SEQUENCE analysis; BODY weight; INFLAMMATION; ANIMAL experimentation; LIQUID chromatography; WESTERN immunoblotting; ONE-way analysis of variance; FUNGI; BLOOD sugar; GENETIC disorders; T-test (Statistics); BILE acids; ENTEROCOCCUS; HUMAN microbiota; ENZYME-linked immunosorbent assay; MASS spectrometry; DESCRIPTIVE statistics; RESEARCH funding; PLANT extracts; LIPID metabolism disorders; GLUCOSE tolerance tests; POLYMERASE chain reaction; DATA analysis software; ANTIOBESITY agents; MICE; DIETARY fats; CHOLESTEROL; PHARMACODYNAMICS
- Publication
American Journal of Chinese Medicine, 2022, Vol 50, Issue 3, p817
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X22500343