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- Title
Proliferative Effects of Chishao on Injured Peripheral Neurons.
- Authors
Fang, Wen-Kuei; Weng, Yi-Jiun; Chang, Mu-Hsin; Lin, Chien-Chung; Chen, Yueh-Sheng; Hsu, Hsi-Hsien; Tsai, Fuu-Jen; Tsai, Chang-Hai; Kuo, Wu-Hsien; Lu, Chung Yen; Huang, Chih-Yang
- Abstract
The aim of the study was to evaluate the proliferative effects of chishao on neuron regeneration. A silicone rubber nerve guide across a 15-mm gap was filled with different concentrations of chishao (0-125 mg/ml) in the dissected sciatic nerve of the right leg in SD rats. The left legs were used as control. After eight weeks, the regenerated nerves showed dose-dependently activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA), decreased plasminogen activator inhibitor-1 (PAI-1) and enhanced proliferative proteins, extracellular signal regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-signalings. The results imply that applying an appropriate dose of chishao would be a potential approach for enhancing neuron regeneration.
- Subjects
FIBRINOLYTIC agents; BLOOD coagulation factors; DOSE-effect relationship in pharmacology; ELECTROPHYSIOLOGY; GROWTH factors; HERBAL medicine; CHINESE medicine; METABOLISM; NERVOUS system regeneration; NEURONS; SCIATIC nerve; TRANSFERASES; DRUG administration
- Publication
American Journal of Chinese Medicine, 2010, Vol 38, Issue 4, p735
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X10008202