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- Title
Serum from interferon-β-1b-treated patients with early multiple sclerosis stabilizes the blood–brain barrier in vitro.
- Authors
Müller, Marcus; Frese, Achim; Nassenstein, Isabelle; Hoppen, Maike; Marziniak, Martin; Ringelstein, Erich Bernd; Kim, Kwang Sik; Schäbitz, Wolf-Rüdiger; Kraus, Jörg
- Abstract
Interferon-β (IFN-β) stabilizes the blood–brain barrier (BBB) in vitro. Here we investigated the effect of serum from 15 IFN-β-1b-treated multiple sclerosis (MS) patients on the permeability read-outs of small solutes in an in vitro BBB model consisting of human brain microvascular endothelial cells in co-culture with rat astrocytes. The addition of sera from IFN-β-treated patients resulted in a significantly (p < 0.05) reduced permeability as compared with untreated patients. Our findings show that sera from IFN-β-1b-treated MS patients have a stabilizing effect on the in vitro BBB. We suggest an unknown potentially pro-inflammatory factor in the serum of MS patients that may lead to a BBB dysfunction and can be modulated by IFN-β.
- Subjects
MULTIPLE sclerosis; INTERFERONS; BLOOD-brain barrier; LABORATORY rats; PERMEABILITY
- Publication
Multiple Sclerosis Journal, 2012, Vol 18, Issue 2, p236
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458511416837