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- Title
Risk variants for psoriasis vulgaris in a large case–control collection and association with clinical subphenotypes.
- Authors
Julià, Antonio; Tortosa, Raül; Hernanz, José Manuel; Cañete, Juan D.; Fonseca, Eduardo; Ferrándiz, Carlos; Unamuno, Pablo; Puig, Lluís; Fernández-Sueiro, José Luís; Sanmartí, Raimon; Rodríguez, Jesús; Gratacós, Jordi; Dauden, Esteban; Sánchez-Carazo, José Luís; López-Estebaranz, José Luís; Moreno-Ramírez, David; Queiró, Rubén; Montilla, Carlos; Torre-Alonso, Juan Carlos; Pérez-Venegas, José Javier
- Abstract
Recent genome-wide association studies (GWASs) have identified >20 new loci associated with the susceptibility to psoriasis vulgaris (PsV) risk. We investigated the association of PsV and its main clinical subphenotypes with 32 loci having previous genome-wide evidence of association with PsV (P < 5e−8) or strong GWAS evidence (P < 5e−5 in discovery and P < 0.05 in replication sample) in a large cohort of PsV patients (n = 2005) and controls (n = 1497). We provide the first independent replication for COG6 (P = 0.00079) and SERPINB8 (P = 0.048) loci with PsV. In those patients having developed psoriatic arthritis (n = 955), we found, for the first time, a strong association with IFIH1 (P = 0.013). Analyses of clinically relevant PsV subtypes yielded a significant association of severity of cutaneous disease with variation at LCE3D locus (P = 0.0005) in PsV and nail involvement with IL1RN in purely cutaneous psoriasis (PsC, P = 0.007). In an exploratory analysis of epistasis, we replicated the previously described HLA-C–ERAP1 interaction with PsC. Our findings show that common genetic variants associated with a complex phenotype like PsV influence different subphenotypes of high clinical relevance.
- Publication
Human Molecular Genetics, 2012, Vol 21, Issue 20, p4549
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/dds295