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- Title
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
- Authors
Charron, Giselle; Doudnikoff, Evelyne; Canron, Marie-Helene; Qin Li; Céline Véga; Marais, Sebastien; Baufreton, Jérôme; Vital, Anne; Oliet, Stéphane H. R.; Bezard, Erwan
- Abstract
The current concept of basal ganglia organization and function in physiological and pathophysiological conditions excludes the most numerous cells in the brain, i.e., the astrocytes, present with a ratio of 10:1 neuron. Their role in neurodegenerative condition such as Parkinson's disease (PD) remains to be elucidated. Before embarking into physiological investigations of the yet-to-be-identified "tripartite" synapses in the basal ganglia in general and the striatum in particular, we therefore characterized anatomically the PD-related modifications in astrocytic morphology, the changes in astrocytic network connections and the consequences on the spatial relationship between astrocytic processes and asymmetric synapses in normal and PD-like conditions in experimental and human PD. Our results unravel a dramatic regulation of striatal astrocytosis supporting the hypothesis of a key role in (dys) regulating corticostriatal transmission. Astrocytes and their various properties might thus represent a therapeutic target in PD.
- Subjects
BASAL ganglia; ASTROCYTES; PARKINSON'S disease; PATHOLOGICAL physiology; NEURODEGENERATION; DEGENERATION (Pathology)
- Publication
Frontiers in Aging Neuroscience, 2014, Vol 6, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2014.00258