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- Title
Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics.
- Authors
Tchoe, Youngbin; Bourhis, Andrew M.; Cleary, Daniel R.; Stedelin, Brittany; Lee, Jihwan; Tonsfeldt, Karen J.; Brown, Erik C.; Siler, Dominic A.; Paulk, Angelique C.; Yang, Jimmy C.; Oh, Hongseok; Ro, Yun Goo; Lee, Keundong; Russman, Samantha M.; Ganji, Mehran; Galton, Ian; Ben-Haim, Sharona; Raslan, Ahmed M.; Dayeh, Shadi A.
- Abstract
Electrophysiological devices are critical for mapping eloquent and diseased brain regions and for therapeutic neuromodulation in clinical settings and are extensively used for research in brain-machine interfaces. However, the existing clinical and experimental devices are often limited in either spatial resolution or cortical coverage. Here, we developed scalable manufacturing processes with a dense electrical connection scheme to achieve reconfigurable thin-film, multithousand-channel neurophysiological recording grids using platinum nanorods (PtNRGrids). With PtNRGrids, we have achieved a multithousand-channel array of small (30 μm) contacts with low impedance, providing high spatial and temporal resolution over a large cortical area. We demonstrated that PtNRGrids can resolve submillimeter functional organization of the barrel cortex in anesthetized rats that captured the tissue structure. In the clinical setting, PtNRGrids resolved fine, complex temporal dynamics from the cortical surface in an awake human patient performing grasping tasks. In addition, the PtNRGrids identified the spatial spread and dynamics of epileptic discharges in a patient undergoing epilepsy surgery at 1-mm spatial resolution, including activity induced by direct electrical stimulation. Collectively, these findings demonstrated the power of the PtNRGrids to transform clinical mapping and research with brain-machine interfaces. Cortex in high resolution: Recording brain cortical activity with high spatial and temporal resolution is critical for understanding brain circuitry in physiological and pathological conditions. In this study, Tchoe et al. developed a reconfigurable and scalable thin-film, multithousand-channel neurophysiological recording grids using platinum nanorods, called PtNRGrids, that could record thousands of channels with submillimeter resolution in the rat barrel cortex. In human subjects, PtNRGrids were able to provide high-resolution recordings of large and curvilinear brain areas and to resolve spatiotemporal dynamics of motor and sensory activities. The results suggest that PtNRGrids could be used in the preclinical and clinical setting for high spatial and temporal recording of neural activity.
- Subjects
BRAIN mapping; BRAIN-computer interfaces; LABORATORY rats; ELECTRIC stimulation; NEURAL circuitry; VAGUS nerve
- Publication
Science Translational Medicine, 2022, Vol 14, Issue 628, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.abj1441