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- Title
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.
- Authors
Sager, Hendrik B.; Dutta, Partha; Dahlman, James E.; Hulsmans, Maarten; Courties, Gabriel; Yuan Sun; Heidt, Timo; Vinegoni, Claudio; Borodovsky, Anna; Fitzgerald, Kevin; Wojtkiewicz, Gregory R.; Yoshiko Iwamoto; Tricot, Benoit; Khan, Omar F.; Kauffman, Kevin J.; Yiping Xing; Shaw, Taylor E.; Libby, Peter; Langer, Robert; Weissleder, Ralph
- Abstract
The article discusses aspects of the progression and complication of the diseases due to the increase of myeloid cell levels support. It examines the destabilization of proteases in atherosclerotic plaques that modifies atherosclerosis risk factors. It also cites the increase of plaque leukocytes following myocardial infarction (MI).
- Subjects
MYOCARDIAL infarction risk factors; ATHEROSCLEROTIC plaque; MYELOID metaplasia; CELL adhesion molecules; LEUCOCYTES
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 342, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf1435