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- Title
Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders, Diffuse Large B-Cell Lymphoma Type, in a Patient with Behçet's Disease Treated with Cyclosporine A.
- Authors
Urano, Yuka; Ohe, Rintaro; Yamada, Akane; Kabasawa, Takanobu; Suzuki, Kazushi; Kitaoka, Takumi; Tamazawa, Nobuyuki; Aung, Naing Ye; Utsunomiya, Aya; Toubai, Tomomi; Ishizawa, Kenichi
- Abstract
A 40-year-old man had been treated for Behçet's disease (BD) with cyclosporine A (CsA) for 14 years. He presented multiple lymphadenopathies with fever. Histological examination of surgical biopsy showed other iatrogenic immunodeficiency-associated lymphoproliferative disorders, diffuse large B-cell lymphoma type with positivity for Epstein-Barr virus encoding RNA-1 (EBER-1). BCL2-IgH, BCL6-IgH, and MYC-IgH translocations were not detected. CsA was stopped, and R-CHOP therapy was initiated. However, his lymphoma was chemotherapy resistant and rapidly progressed. To the best of our knowledge, this is the first case of diffuse large B-cell lymphoma that occurred in a BD patient treated with CsA reported in English. Both BD and CsA are associated with the pathogenesis of lymphoma. We also describe extremely rare cases in the form of a literature review.
- Subjects
BEHCET'S disease; LYMPHOPROLIFERATIVE disorders; DIFFUSE large B-cell lymphomas; CYCLOSPORINE; IATROGENIC diseases; LYMPHOMAS
- Publication
Case Reports in Oncology, 2020, Vol 13, Issue 3, p1145
- ISSN
1662-6575
- Publication type
Article
- DOI
10.1159/000510362