We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Tyrosine Kinase Inhibitor Induced Isolated Pericardial Effusion.
- Authors
Agrawal, Vineet; Christenson, Eric S.; Showel, Margaret M.
- Abstract
Long-term therapy with tyrosine kinase inhibitors (TKI) has resulted in improved outcomes for patients suffering from Bcr-Abl fusion protein-harboring leukemias. As a result, a growing population of patients on TKI therapy present to their primary care providers. In this case, we report on the case of a 62-year-old male who presented with a symptomatic pericardial effusion. After pericardiocentesis, malignancy and infectious etiologies were excluded. The pericardial effusion was attributed to his TKI, with a transition of this medication to a different TKI. A repeat evaluation 1 month following the withdrawal of the offending agent showed no recurrence of his pericardial effusion on echocardiogram. In this report, we will highlight a rare but important side effect of TKI therapy before discussing its purported mechanisms and differing incidence rates. Early recognition of serosal inflammation related to long-term TKI therapy by primary care providers is important in preventing patient morbidity and mortality. © 2015 S. Karger AG, Basel
- Publication
Case Reports in Oncology, 2015, Vol 8, Issue 1, p88
- ISSN
1662-6575
- Publication type
Article
- DOI
10.1159/000375484