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- Title
Sinus augmentation using rhBMP‐2/ACS in a mini‐pig model: Influence of an adjunctive ceramic bone biomaterial.
- Authors
Susin, Cristiano; Lee, Jaebum; Fiorini, Tiago; de Freitas, Rubens Moreno; Chiu, Hsien‐Chung; Prasad, Hari S.; Buxton, Amanda N.; Wikesjö, Ulf M. E.
- Abstract
Abstract: Background: Recombinant human bone morphogenetic protein‐2 in an absorbable collagen sponge carrier (rhBMP‐2/ACS) has been shown to support significant bone formation when used to augment the maxillary sinus for implant dentistry. Nevertheless, bone biomaterials have been suggested to extend rhBMP‐2/ACS with limited support of the merits of such approaches. Objectives: To evaluate local bone formation/dental implant osseointegration following implantation of rhBMP‐2/ACS combined with a ceramic bone biomaterial using a mini‐pig sinus augmentation model. Methods: Twelve adult Göttingen mini‐pigs received rhBMP‐2/ACS (rhBMP‐2 adjusted to 0.43 mg/cc) alone or combined with an off‐the‐shelf biphasic ceramic (15%/85% HA/ß‐TCP) biomaterial at 3:1, 1:1 and 1:3 ratios randomized to contra‐lateral maxillary sinus sites yielding rhBMP‐2/ACS fractions of 100%, 75%, 50% and 25%, respectively. A 4‐cc implant volume was used for all sites. Two threaded dental implants (ø4.0 × 11.5 mm) were placed at each site. The animals were euthanized at 8 weeks for histologic analysis. Results: Surgical execution and healing were generally uneventful, infraorbital local swelling was observed in all animals until suture removal. rhBMP‐2/ACS combined with the ceramic biomaterial did not significantly enhance local bone formation (range 9.0 ± 1.5 to 9.7 ± 2.1 mm) compared with rhBMP‐2/ACS alone (8.6 ± 1.1 mm; p > 0.05). Variations in rhBMP‐2/ACS to ceramic matrix ratios yielding rhBMP‐2 doses approximating 0.4, 0.9, 1.3 and 1.7 mg/sinus did not appreciably influence bone formation/osseointegration. Conclusions: Whereas rhBMP‐2/ACS supports significant bone formation/osseointegration in the mini‐pig sinus augmentation model and thus appears an effective alternative for sinus augmentation procedures, adding a ceramic biomaterial to rhBMP‐2/ACS does not produce meaningful biological advantages.
- Subjects
SINUS augmentation; BONE morphogenetic proteins; MINIATURE pigs as laboratory animals; BIOCERAMICS; BONE physiology; OSSEOINTEGRATED dental implants; PATIENTS; MAXILLARY sinus surgery; BONE growth; ANIMAL experimentation; BIOLOGICAL models; BIOMEDICAL materials; COLLAGEN; EUTHANASIA; HISTOLOGY; DENTAL implants; INFLAMMATION; ORAL surgery; SWINE; OSSEOINTEGRATION; TREATMENT effectiveness
- Publication
Journal of Clinical Periodontology, 2018, Vol 45, Issue 8, p1005
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12921