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- Title
Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta‐analysis.
- Authors
Fan, Yu‐Xin; Wu, Jiang‐Hai; Yin, Sun‐Jun; Zhou, Tao; Huang, Yan‐Hua; Meng, Rui; Wang, Ping; He, Gong‐Hao
- Abstract
Objective: FOXP3 single nucleotide polymorphisms (SNPs) were recently elucidated to influence the development of preeclampsia (PE), but the results on this issue still remained controversial. Thus, a meta‐analysis was implemented to systematically investigate the roles of FOXP3 SNPs in PE. Methods: Eligible publications were identified by retrieving relevant electronic databases. Meanwhile, the association intensity was estimated by calculating odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models. Results: Totally eight investigations involving 3446 subjects were enrolled in the final meta‐analysis. The AC and AC + CC genotypes of FOXP3 rs3761548 were related to the susceptibility of PE in over‐dominant (OR = 1.19, 95%CI = 1.02‐1.38, P = 0.03) and recessive (OR = 0.59, 95% CI: 0.36‐0.97, P = 0.04) models. Furthermore, correlation between rs2232365 and PE was observed in recessive model (GG vs. GA + AA) (OR = 0.79, 95%CI: 0.65‐0.97, P = 0.03). Moreover, rs2232365 GA and GG + GA genotypes were associated with the severity of PE. However, rs4824747, rs3761547 and rs2280883 polymorphisms had no significant impact on PE susceptibility. Conclusions: FOXP3 rs3761548 and rs2232365 SNPs influenced the PE susceptibility and therefore may be potential biomarkers for prediction of PE risk.
- Subjects
GENETIC polymorphisms; SINGLE nucleotide polymorphisms; PREECLAMPSIA; GENETIC models; GENOTYPES
- Publication
American Journal of Reproductive Immunology, 2022, Vol 88, Issue 1, p1
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.13554