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- Title
Effect of L-theanine on sensorimotor gating in healthy human subjects.
- Authors
Ota, Miho; Wakabayashi, Chisato; Matsuo, Junko; Kinoshita, Yukiko; Hori, Hiroaki; Hattori, Kotaro; Sasayama, Daimei; Teraishi, Toshiya; Obu, Satoko; Ozawa, Hayato; Kunugi, Hiroshi
- Abstract
Aim l-Theanine ( N-ethyl- l-glutamine) is an amino acid uniquely found in green tea. Growing evidence has suggested the possible effects of l-theanine on cognition. Previously, we found that l-theanine attenuates MK-801-induced deficit in prepulse inhibition ( PPI) in mice. In this study, we examined the effect of l-theanine in increasing the PPI in healthy humans. Methods The subjects were 14 healthy adults who underwent PPI testing as a measure of sensorimotor gating 90 min after an oral intake of l-theanine (0, 200, 400, or 600 mg). PPI tests were done by examiners who were blind to the dose. Results The administration of 200 mg of l-theanine and that of 400 mg, but not 600 mg, significantly increased the % PPI compared to the baseline (0 mg). There was no significant relation between the dose of l-theanine and the startle magnitude or the habituation of startle response. The plasma concentrations of l-theanine correlated with the dose of l-theanine. Conclusion The observed effect with 200-400 mg of l-theanine on PPI suggested that l-theanine at a particular dose range increases sensorimotor gating in humans.
- Subjects
THEANINE; COGNITION; GLUTAMINE; AMINO acids; DRUG dosage
- Publication
Psychiatry & Clinical Neurosciences, 2014, Vol 68, Issue 5, p337
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/pcn.12134