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- Title
Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii.
- Authors
Cebrero-Cangueiro, T; Nordmann, P; Carretero-Ledesma, M; Pachón, J; Pachón-Ibáñez, M E
- Abstract
<bold>Objectives: </bold>To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus meropenem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58.<bold>Methods: </bold>An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. baumannii clinical isolates. The efficacies of the carbapenems in monotherapy and in combination were tested.<bold>Results: </bold>Meropenem was better than imipenem in mice infected with either of the carbapenem-resistant A. baumannii (CRAb) strains. The combination of meropenem plus imipenem significantly improved the clearance of CRAbs from spleen compared with non-treated groups. The carbapenem-containing combination was better than imipenem for treating mice infected with both carbapenemase producers. In blood, the carbapenem combination significantly decreased the bacterial load of the OXA-23 producers compared with imipenem or meropenem used in monotherapy.<bold>Conclusions: </bold>These results suggest that dual carbapenem combination could be an option for the treatment of infections due to carbapenemase-producing A. baumannii such as OXA-23 and OXA-58 producers.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2021, Vol 76, Issue 3, p680
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkaa487