We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
CRITICAL ISSUES RELATED TO TRANSFERSOMES - NOVEL VESICULAR SYSTEM.
- Authors
Vinod, Kombath Ravindran; Kumar, Minumula Suneel; Anbazhagan, Sockalingam; Sandhya, Subadhra; Saikumar, Parre; Rohit, Reddy Tera; Banji, David
- Abstract
It has become increasingly apparent that vesicular drug delivery elicits modest possessions in drug targeting. Transfersomes are a form of elastic or deformable vesicle, which were fi rst introduced in the early 1990s. Elasticity can be achieved by using an edge activator in the lipid bilayer structure. Molecules greater than 500 Da normally do not cross the skin. This prevents epicutaneous delivery of the high molecular weight therapeutics as well as non-invasive trans-cutaneous immunisation. Transdermal route will always remain a lucrative area for drug delivery. With the advent of new categories of drugs like peptides this route has captured more focus to combat the problems related to their delivery through oral route. But the transdermal route is equally fi lled with the hopes and disappointments as the transport of drug through this route faces many problems especially for the large molecules. To answer this problem many approaches were adopted. One of the very recent approaches is the use of ultra-deformable carrier systems (transfersomes). The y have been used as drug carriers for a range of small molecules, peptides, proteins and vaccines, both in vitro and in vivo. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. This is because of its deformable nature. The aim of this article is explanation the formation of micelle and vesicles, various types of vesicles, specifi cally focusing on tran
- Subjects
DRUG delivery systems; TARGETED drug delivery; BILAYER lipid membranes; MOLECULAR weights; MICELLES; LASER microscopy; PEPTIDES
- Publication
Acta Scientiarum Polonorum. Technologia Alimentaria, 2012, Vol 11, Issue 1, p67
- ISSN
1644-0730
- Publication type
Article