We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Resveratrol Inhibits Respiratory Syncytial Virus-Induced IL-6 Production, Decreases Viral Replication, and Downregulates TRIF Expression in Airway Epithelial Cells.
- Authors
Xie, Xiao-hong; Zang, Na; Li, Si-min; Wang, Li-jia; Deng, Yu; He, Yun; Yang, Xi-qiang; Liu, En-mei
- Abstract
Respiratory syncytial virus (RSV) is the most common pathogen responsible for lower respiratory diseases in children. So far, there is no effective treatment or preventative vaccine available for RSV infection, although ribavirin and dexamethasone are commonly prescribed. Resveratrol has been shown to inhibit the replication of several other viruses, thus the effect of resveratrol on RSV-induced inflammatory mediators in 9HTEo cell cultures was evaluated, and possible mechanisms of action were explored and compared with dexamethasone and ribavirin. Incubation with resveratrol resulted in decreased IL-6 production and partial inhibition of RSV replication. Resveratrol treatment also inhibited virus-induced TIR-domain-containing adapter-inducing interferon-β (TRIF) and TANK binding kinase 1 (TBK1) protein expression. These data demonstrate the ability of resveratrol to inhibit cytokine production by RSV in airway epithelial cells, indicating that it might be a therapeutic agent with both anti-inflammatory and antiviral potential for the treatment of RSV infection.
- Subjects
RESPIRATORY syncytial virus; EPITHELIAL cells; RESVERATROL; CYTOKINES; INFLAMMATION; PEDIATRIC respiratory diseases; VIRAL replication
- Publication
Inflammation, 2012, Vol 35, Issue 4, p1392
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-012-9452-7