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- Title
The Value of Measuring Inspiratory Capacity in Subjects With Cystic Fibrosis.
- Authors
Vilozni, Daphna; Dagan, Adi; Lavie, Moran; Sarouk, Ifat; Bar-Aluma, Bat-El; Ashkenazi, Moshe; Mendelovich, Sarina Levy; Betzalel, Yael; Efrati, Ori
- Abstract
BACKGROUND: Inspiratory capacity (IC) is often overlooked as an important measured index of spirometry in patients with cystic fibrosis (CF). Abnormally low IC may indicate the onset of static/dynamic hyperinflation, which may be accompanied by dyspnea and an increase in the work of breathing. This cross-sectional study sought to determine whether measuring IC during spirometry, may add clinical value to FEV1 measurements in CF subjects. METHODS: Anthropometric, clinical, spirometry, and static lung volume data were gathered retrospectively from 98 of 165 subjects with CF (mean ± SD age 26.8 ± 11.0 y) registered in The Edmond and Lily Safra Children's Hospital, Sheba Medical Centre, Israel. We compared the IC (% predicted) to FEV1, static lung volumes, and hospitalization days/year. RESULTS: IC decreased alongside FEV1 decline but at a slower pace (r² = 0.32). Incremental trapped air, as measured by residual volume (RV), and a rapid elevation in the ratio of RV to total lung capacity occurred when IC deteriorated below 60% predicted values. The unique combination of IC < 50% predicted and FEV1 > 40% predicted induced an increase of up to 125 hospitalization days/year compared to subjects having IC > 50% predicted (up to 73 d/y, P < .001). CONCLUSIONS: Measuring IC in CF subjects may reveal silent worsening of lung function as indicated by a decline in IC < 50% predicted while FEV1 is still > 40% predicted. This condition may lead to inefficient breathing at high lung volumes, which may explain a subjective sensation of breathlessness and lead to an increase in hospitalization days/year.
- Subjects
ISRAEL; CONFIDENCE intervals; STATISTICAL correlation; CYSTIC fibrosis; PLETHYSMOGRAPHY; RESEARCH funding; RESPIRATION; SPIROMETRY; STATISTICS; T-test (Statistics); DATA analysis; PREDICTIVE tests; CONTINUING education units; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics; LUNG volume measurements; MANN Whitney U Test
- Publication
Respiratory Care, 2018, Vol 63, Issue 8, p981
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.05920