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- Title
Inhomogeneity of Cellular Refractoriness in Human Atrium: Factor of Arrhythmia?
- Authors
Boutjdir, Mohamed; Le Heuzey, Jean Yves; Lavergne, Thomas; Chauvaud, Sylvain; Guize, Louis; Carpentier, Alain; Peronneau, Pierre
- Abstract
Spatial inhomogeneity of refractory periods, us measured during clinical electrophysiological studies, is a known predisposing factor of arrhythmia. We studied effective refractory periods (ERP) and action potential duration (ADP90) on isolated human atrium. Twelve samples of right atrium obtained during cardiac surgery from patients with (n = 6) arid without (n = 6) atrial fibrillation (Af) were studied by microelectrode technique. For each preparation. ERP were measured cit basic cycle lengths (BCL) of 1,600, 1,200, 800, and 400 msec in five different cells located around (0.8 mm) the stimulating electrode. Dispersion of ERP was significantly greater in t he AF group (96.7 ± 9 versus 70.9 ± 9 msec, p = 0.01). In the non-AF group, we observed a positive linear correlation between (1) ERP and BOL (r = 0.86) (2) ADP90 and BCL (r = 0.93). On the contrary, in the AF group this correlation was absent between ERP and BCL (r = 0.28), poor between ADP90 arid BCL (r = 0.62). These results suggest that nonhomogeneous recovery of excitability (dispersion and poor adaptation) may be an important factor of arrhythmia. This inhomogeneity is present at the cellular level as well as in the entire heart.
- Subjects
ARRHYTHMIA; HEART diseases; HEART beat; CARDIAC surgery patients; PATIENTS; SURGERY
- Publication
Pacing & Clinical Electrophysiology, 1986, Vol 9, Issue 6, p1095
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/j.1540-8159.1986.tb06676.x