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- Title
Community-Associated Extended-Spectrum β-Lactamase–Producing Escherichia coli Infection in the United States.
- Authors
Doi, Yohei; Park, Yoon Soo; Rivera, Jesabel I.; Adams-Haduch, Jennifer M.; Hingwe, Ameet; Sordillo, Emilia M.; Lewis, James S.; Howard, Wanita J.; Johnson, Laura E.; Polsky, Bruce; Jorgensen, James H.; Richter, Sandra S.; Shutt, Kathleen A.; Paterson, David L.
- Abstract
During 2009 and 2010, an observational study in US hospitals found that a substantial portion community-onset, ESBL-producing E. coli infections now occur among patients without discernible healthcare-associated risk factors. This epidemiologic shift has implications for the empiric management of community-associated infection when involvement of E. coli is suspected. Background. The occurrence of community-associated infections due to extended-spectrum β-lactamase (ESBL)–producing Escherichia coli has been recognized as a major clinical problem in Europe and other regions.Methods. We conducted a prospective observational study to examine the occurrence of community-associated infections due to ESBL-producing E. coli at centers in the United States. Five academic and community hospitals and their affiliated clinics participated in this study in 2009 and 2010. Sites of acquisition of the organisms (community-associated or healthcare-associated), risk factors, and clinical outcome were investigated. Screening for the global epidemic sequence type (ST) 131 and determination of the ESBL types was conducted by polymerase chain reaction and sequencing.Results. Of the 291 patients infected or colonized with ESBL-producing E. coli as outpatients or within 48 hours of hospitalization, 107 (36.8%) had community-associated infection (81.5% of which represented urinary tract infection), while the remainder had healthcare-associated infection. Independent risk factors for healthcare-associated infection over community-associated infection were the presence of cardiovascular disease, chronic renal failure, dementia, solid organ malignancy, and hospitalization within the previous 12 months. Of the community-associated infections, 54.2% were caused by the globally epidemic ST131 strain, and 91.3% of the isolates produced CTX-M–type ESBL.Conclusions. A substantial portion of community-onset, ESBL-producing E. coli infections now occur among patients without discernible healthcare-associated risk factors in the United States. This epidemiologic shift has implications for the empiric management of community-associated infection when involvement of E. coli is suspected.
- Subjects
UNITED States; BACTERIAL diseases; ESCHERICHIA coli; BETA lactamases; COMMUNITY-based clinical trials; SCIENTIFIC observation; HEALTH risk assessment
- Publication
Clinical Infectious Diseases, 2013, Vol 56, Issue 5, p641
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/cis942