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- Title
A re-examination of antidepressant treatment-emergent mania in bipolar disorders: evidence of gender differences.
- Authors
Scott, J.; Brichant‐Petitjean, C.; Etain, B.; Henry, C.; Kahn, J.‐P.; Azorin, J.‐M.; Leboyer, M.; Bellivier, F.
- Abstract
Objective To explore the prevalence and clinical profile of males and females who develop antidepressant treatment-emergent mania ( ATEM). Method From an original sample of 754 patients with BD, we identified ATEM+ cases ( n = 75) and ATEM- controls ( n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases. Results Seventy-five individuals were classified as ATEM+; 87% of ATEM events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and/or substance use disorder [Odds Ratio ( OR) 6.37], a history of one or more suicide attempts ( OR 4.19) and higher number of depressive episodes per year of illness ( OR 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder ( OR 3.23), a positive family history of BD I ( OR 2.68) and depressive onset polarity ( OR 2.01). Conclusion Using stringent definitions of ATEM status to reduce the probability of inclusion of false-positive cases and false-negative controls, we identified for the first time that the risk profiles for the development of an ATEM differ significantly according to gender.
- Subjects
MANIA; BIPOLAR disorder; GENDER differences (Psychology); ANTIDEPRESSANTS; MENTAL depression
- Publication
Acta Psychiatrica Scandinavica, 2017, Vol 135, Issue 5, p479
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/acps.12728