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- Title
Salmonella enterica serovar Typhi in Japan, 2001-2006: emergence of high-level fluoroquinolone-resistant strains.
- Authors
Morita, M.; Hirose, K.; Takai, N.; Terajima, J.; Watanabe, H.; Sagara, H.; Kurazono, T.; Yamaguchi, M.; Kanazawa, Y.; Oyaizu, T.; Izumiya, H.
- Abstract
The phage types and antimicrobial susceptibilities of 226 isolates of Salmonella enterica serovar Typhi from imported cases in Japan between 2001 and 2006 were investigated. Most (93.8%) had travelled to Asian countries, particularly South East Asia. Twenty-one phage types were identified with E1 (30.5%), UVS (15.9%) and B1 (9.3%) being the most common. The frequency of multidrug-resistant strains reached 37.0% in 2006 with phage types E1 and E9 predominating. Almost half (48.2%) of the isolates were resistant to nalidixic acid and two isolates displayed high-level fluoroquinolone resistance. Three mutations, two in gyrA and one in parC, were identified in both isolates.
- Subjects
JAPAN; SALMONELLA; ENTEROBACTERIACEAE; FLUOROQUINOLONES; GRAM-negative bacteria; ANTI-infective agents
- Publication
Epidemiology & Infection, 2010, Vol 138, Issue 3, p318
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S0950268809990380