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- Title
AGENT-BASED MODELS OR DIFFERENTIAL EQUATIONS:: TWO WAYS TO LEARN ABOUT SELECTION MECHANISMS IN GERMINAL CENTRES.
- Authors
MEYER-HERMANN, MICHAEL
- Abstract
The germinal centre reaction selects B cells from a large diversity of clones in order to optimise the efficiency of an immune response. We discuss two rather different approaches to tackle the puzzle of selection mechanisms in germinal centres with mathematical methods. A space-averaged differential equation approach is compared to a space-resolved agent-based approach. The same two novel selection mechanisms could be localised with both methods which increases the predictive power of the result. In addition, the comparison of both methods allows interesting conclusions about the suitability of diverse approaches in Theoretical Biology.
- Subjects
GERMINAL centers; IMMUNE response; GOLGI apparatus; MATHEMATICAL models; BIOLOGICAL systems
- Publication
Biophysical Reviews & Letters, 2008, Vol 3, Issue 1/2, p313
- ISSN
1793-0480
- Publication type
Article
- DOI
10.1142/S1793048008000770