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- Title
Senescent T Cells Predict the Development of Hyperglycemia in Humans.
- Authors
Yong-ho Lee; So Ra Kim; Dai Hoon Han; Hee Tae Yu; Yoon Dae Han; Jin Hee Kim; Soo Hyun Kim; Chan Joo Lee; Byoung-Hoon Min; Dong-Hyun Kim; Kyung Hwan Kim; Jin Won Cho; Won-Woo Lee; Eui-Cheol Shin; Sungha Park; Lee, Yong-Ho; Kim, So Ra; Han, Dai Hoon; Yu, Hee Tae; Han, Yoon Dae
- Abstract
Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during follow-up (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.
- Subjects
T cells; HYPERGLYCEMIA; CARDIOVASCULAR diseases; CD8 antigen; CD28 antigen; DIABETES; ADIPOSE tissues
- Publication
Diabetes, 2019, Vol 68, Issue 1, p156
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db17-1218