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- Title
Does the Association of the Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio with Insulin Resistance Differ by Race or Ethnicity?
- Authors
Li, Chaoyang; Ford, Earl S.; Meng, Yuan-Xiang; Mokdad, Ali H.; Reaven, Gerald M.
- Abstract
The triglyceride/high-density lipoprotein cholesterol concentration ratio (TG/HDL-C) has been reported to be significantly correlated with the fasting insulin concentration, and therefore a clinically useful way to identify the concomitant presence of insulin resistance (IR) and dyslipidemia. However, TG/HDL-C was not found to be related to IR among African Americans. We sought to examine whether the association of TG/HDL-C with fasting serum insulin concentration (FSI); a surrogate measure of IR, may differ across three racial or ethnic groups in the United States. Using data on 2652 men and non-pregnant women without diabetes age ≥20 years from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 (49.4% men; 82.2% whites, 10.5% blacks, and 7.3% Mexican Americans), we estimated the correlations between TG/HDL-C and FSI and assessed the predictive value of TG/HDL-C for hyperinsulinemia defined using the 75th percentile of fasting insulin concentration among nondiabetic adults in NHANES III (1988-1994) as a cutoff value with a receiver operating characteristic curve analysis by race or ethnicity. The Pearson correlation coefficient between log-transformed TG/HDL-C and FSI was 0.48, 0.44, and 0.47 for whites, blacks, and Mexican Americans, respectively. After adjustment for age, socioeconomic status, smoking status, systolic blood pressure, waist circumference, total cholesterol, and C-reactive protein, the association of TG/HDL-C with FSI remained statistically significant in the three racial or ethnic groups (all p values <0.01). No statistically significant interaction between race and TG/HDL-C on FSI was detected (p >0.10). The area under curve for TG/HDL-C and hyperinsulinemia was 0.774, 0.744, and 0.745 for whites, blacks, and Mexican Americans, respectively. In conclusion, the significant association between TG/HDL-C and FSI appeared to be consistent across the three racial or ethnic groups in this nationally representative sample.
- Subjects
UNITED States; TRIGLYCERIDES; HIGH density lipoproteins; CHOLESTEROL; INSULIN resistance; HEALTH of minorities; C-reactive protein
- Publication
Diabetes, 2007, Vol 56, pA271
- ISSN
0012-1797
- Publication type
Article