We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Low Circulating Endogenous Secretory Receptor for AGEs (esRAGE) Predicts Progression to Overt Nephropathy in Subjects with Type 2 Diabetes.
- Authors
Koyama, Hidenori; Shoji, Takuhito; Tanaka, Shinji; Fukumoto, Shinya; Kimoto, Eiji; Mori, Katsuhito; Emoto, Masanori; Shoji, Tetsuo; Yamamoto, Yasuhiko; Watanabe, Takuo; Yamamoto, Hiroshi; Nishizawa, Yoshiki
- Abstract
Receptor for advanced glycation end-products (RAGE) is involved in diabetic vascular complications. We have recently shown that plasma endogenous secretory RAGE (esRAGE), an alternatively spliced form of RAGE, is closely associated with metabolic syndrome, atherosclerosis and cardiovascular mortality. Here, we evaluated if plasma esRAGE is a predictor of progression to overt proteinuria in type 2 diabetes. A prospective observational cohort study was performed for 269 type 2 diabetic patients, including 190 patients with normoalbuminuria (<30 mg/g creatinine) and 79 with microalbuminuria (30-299 mg/g creatinine), recruited at baseline (1996-2002). Plasma esRAGE was measured by ELISA at baseline. The patients were followed up until progression to overt proteinuria (albuminuria 300 mg/g creatinine or more) or to July 2006 if the patients remained at normo- or microalbuminuria. The median follow-up period of the subjects was 62 (4-123) months. Kaplan-Meier analyses revealed that the lowest tertile of plasma esRAGE showed significantly higher occurrence of overt proteinuria. Univariate Cox proportional hazards analyses showed that hazards ratio for the lowest tertile of plasma esRAGE against the highest or the middle tertile was 2.56 (95% confidence intervals: 1.06-6.25) or 2.78 (1.16-6.67), respectively. Multivariate Cox models revealed that the association of low circulating esRAGE with the progression to overt proteinuria was confounded by the presence of microalbuminuria, but was barely affected by the other factors including gender, blood pressure, glycemic control, serum creatinine, treatments for blood pressure, and the presence of retinopathy. Thus, low circulating esRAGE is associated with a higher risk of progression to overt nephropathy.
- Subjects
CELL receptors; DIABETIC nephropathies; PEOPLE with diabetes; TYPE 2 diabetes; PROTEINURIA; ALBUMINURIA
- Publication
Diabetes, 2007, Vol 56, pA200
- ISSN
0012-1797
- Publication type
Article