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- Title
The Roles of Imaging Biomarkers in the Management of Chronic Neuropathic Pain.
- Authors
Pricope, Cosmin Vasilica; Tamba, Bogdan Ionel; Stanciu, Gabriela Dumitrita; Cuciureanu, Magdalena; Neagu, Anca Narcisa; Creanga-Murariu, Ioana; Dobrovat, Bogdan-Ionut; Uritu, Cristina Mariana; Filipiuc, Silviu Iulian; Pricope, Bianca-Mariana; Alexa-Stratulat, Teodora
- Abstract
Chronic neuropathic pain (CNP) affects around 10% of the general population and has a significant social, emotional, and economic impact. Current diagnosis techniques rely mainly on patient-reported outcomes and symptoms, which leads to significant diagnostic heterogeneity and subsequent challenges in management and assessment of outcomes. As such, it is necessary to review the approach to a pathology that occurs so frequently, with such burdensome and complex implications. Recent research has shown that imaging methods can detect subtle neuroplastic changes in the central and peripheral nervous system, which can be correlated with neuropathic symptoms and may serve as potential markers. The aim of this paper is to review available imaging methods used for diagnosing and assessing therapeutic efficacy in CNP for both the preclinical and clinical setting. Of course, further research is required to standardize and improve detection accuracy, but available data indicate that imaging is a valuable tool that can impact the management of CNP.
- Subjects
NEURALGIA; CHRONIC pain; PERIPHERAL nervous system; CENTRAL nervous system
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 21, p13038
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232113038