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- Title
Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing.
- Authors
Liu, Zhiguo; Wu, Tianwen; Xiang, Guangming; Wang, Hui; Wang, Bingyuan; Feng, Zheng; Mu, Yulian; Li, Kui
- Abstract
The major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic manipulation have been fundamentally revolutionized. Agricultural animals with traits of interest can be obtained in just one generation (and without long time selection). Here, we reviewed the advancements of the CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) genome editing tools and their applications in animal breeding, especially in improving disease resistance, production performance, and animal welfare. Additionally, we covered the regulations on genome-edited animals (GEAs) and ways to accelerate their use. Recommendations for how to produce GEAs were also discussed. Despite the current challenges, we believe that genome editing breeding and GEAs will be available in the near future.
- Subjects
GENOME editing; ANIMAL genetic engineering; ANIMAL diseases; NATURAL immunity; GENETIC engineering; ANIMAL breeding
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 13, p7331
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23137331