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- Title
Cut-Off Values of Hematologic Parameters to Predict the Number of Alpha Genes Deleted in Subjects with Deletional Alpha Thalassemia.
- Authors
Velasco-Rodríguez, Diego; Blas, Carlos; Alonso-Domínguez, Juan-Manuel; Vega, Gala; Soto, Carlos; García-Raso, Aránzazu; Llamas-Sillero, Pilar
- Abstract
Most α-thalassemia cases are caused by deletions of the structural α-globin genes. The degree of microcytosis and hypochromia has been correlated with the number of affected α-globin genes, suggesting a promising role of hematologic parameters as predictive diagnostic tools. However, cut-off points for these parameters to discriminate between the different subtypes of α-thalassemia are yet to be clearly defined. Six hematologic parameters (RBC, Hb, MCV, MCH, MCHC and RDW) were evaluated in 129 cases of deletional α-thalassemia (56 heterozygous α+ thalassemia, 36 homozygous α+ thalassemia, 29 heterozygous α0 thalassemia and 8 cases of Hb H disease). A good correlation between the number of deleted alpha genes and MCV (r = -0.672, p < 0.001), MCH (r = -0.788, p < 0.001) and RDW (r = 0.633, p < 0.001) was observed. The presence of an α0 allele should be discarded in individuals with microcytosis without iron deficiency and normal values of Hb A2 and Hb F with MCH < 23.40 pg. Furthermore, MCH < 21.90 pg and/or MCV < 70.80 fL are strongly suggestive of the presence of one α0 allele. Finally, an accurate presumptive diagnosis of Hb H disease can be made if both RDW ≥ 20% and MCH < 19 pg are seen.
- Subjects
ALPHA-Thalassemia; DELETION mutation; HEMATOLOGY; ANEMIA diagnosis; DIFFERENTIAL diagnosis
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 12, p2707
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18122707