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- Title
Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice.
- Authors
Po-Yuan Wu; Jia-Ling Lyu; Yi-Jung Liu; Ting-Yi Chien; Hao-Cheng Hsu; Kuo-Ching Wen; Hsiu-Mei Chiang
- Abstract
Chronic ultraviolet (UV) exposure may cause skin damage, disrupt skin barrier function, and promote wrinkle formation. UV induces oxidative stress and inflammation, which results in extracellular matrix degradation in the dermis and epidermal hyperplasia. Our previous study demonstrated that fisetin exerts photoprotective activity by inhibiting mitogen-activated protein kinase/activator protein-1/matrix metalloproteinases (MMPs) activation. In this study, fisetin was applied topically to investigate its antiphotodamage effects in hairless mice. The erythema index (a* values) and transepidermal water loss were evaluated to assess skin damage, and immunohistochemical staining was conducted to elucidate the photoprotective mechanism of fisetin. The results revealed that the topical application of fisetin reduced UVB-induced increase in the a* value and wrinkle formation. In addition, fisetin inhibited epidermal hyperplasia and increased the collagen content in the dermis. Fisetin exerted photoprotective activity by inhibiting the expression of MMP-1, MMP-2, and cyclooxygenase-2 and increasing the expression of nuclear factor erythroid 2-related factor. Furthermore, fisetin increased the expression of filaggrin to prevent UVB-induced barrier function disruption. Altogether, the present results provide evidence of the effects and mechanisms of fisetin's antiphotodamage and antiphotoinflammation activities.
- Subjects
SKIN disease treatment; EFFECT of ultraviolet radiation on skin; FLAVONOLS; SKIN inflammation; CYCLOOXYGENASE 2; TRANSCRIPTION factors; GENE expression; THERAPEUTICS
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 10, p2118
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18102118