We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus.
- Authors
Amin, Muhammad Usman; Khurram, Muhammad; Khan, Taj Ali; Faidah, Hani S.; Shah, Zia Ullah; Ur Rahman, Shafiq; Haseeb, Abdul; Ilyas, Muhammad; Ullah, Naseem; Sahibzada Muhammad Umar Khayam; Iriti, Marcello
- Abstract
The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics were determined and results showed an increased activity of flavonoids with antibiotics. The synergistic, additive, or antagonistic relationships between flavonoids (L and Q + L) and antibiotics were also evaluated, and additive and synergistic effects were observed for some antibiotic + flavonoid combinations. In addition, some combinations were also found to damage the bacterial cytoplasmic membrane, as assessed through potassium leakage assay. The effects of flavonoids and flavonoids + antibiotics on mecA gene mutations were also tested, and no functional variation was detected in the coding region.
- Subjects
FLAVONOIDS; QUERCETIN; METHICILLIN-resistant staphylococcus aureus; CELL membranes; DRUG resistance in microorganisms
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 11, p1947
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17111947