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- Title
Profiles of responses of immunological factors to different subtypes of Kawasaki disease.
- Authors
Yan Ding; Gang Li; Li-Juan Xiong; Wei Yin; Jie Liu; Fan Liu; Rui-Geng Wang; Kun Xia; Shu-Ling Zhang; Lei Zhao; Ding, Yan; Li, Gang; Xiong, Li-Juan; Yin, Wei; Liu, Jie; Liu, Fan; Wang, Rui-Geng; Xia, Kun; Zhang, Shu-Ling; Zhao, Lei
- Abstract
<bold>Background: </bold>The responses of immunological factors to different subtypes of Kawasaki disease (KD) remain poorly understood.<bold>Methods: </bold>We recruited 388 patients with KD, 160 patients with infectious febrile disease and 85 normal children who served as control subjects. Both the levels and percentages of T lymphocyte subsets, natural killer cells (NK cells) and B cells were analyzed via flow cytometry. The levels of serum IgG, IgM, IgA and C3, C4 were assessed via velocity scatter turbidimetry.<bold>Results: </bold>The most significant differences noted between the patients with infectious febrile disease and the normal children were the elevated levels of B cells, C3 and the ratio of CD4/CD8, and the decreased levels of CD8+ T cells and NK cells, as well as the moderate increase in the absolute value of the CD3+ cells. The decreased T cell levels and the elevated B cell levels were helpful in distinguishing typical KD from atypical KD; the elevated T cell levels, the elevated NK cell and B cell levels and the decreased B cell levels were helpful in predicting the effectiveness of IVIG; low C3 and C4 levels were linked with prodromal infections.<bold>Conclusions: </bold>Lymphocytes subsets and complement markers may be useful in differentiating among the different subtypes of KD and in helping clinicians understand the pathophysiology of KD.
- Subjects
MUCOCUTANEOUS lymph node syndrome; T cells; IMMUNOLOGY; KILLER cells; IMMUNOGLOBULIN M; CD4 antigen; FEVER; IMMUNOGLOBULINS; CASE-control method; LYMPHOCYTE subsets
- Publication
BMC Musculoskeletal Disorders, 2015, Vol 16, p1
- ISSN
1471-2474
- Publication type
journal article
- DOI
10.1186/s12891-015-0744-6