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- Title
Emergence of multidrug-resistant <italic>Providencia rettgeri</italic> isolates co-producing NDM-1 carbapenemase and PER-1 extended-spectrum β-lactamase causing a first outbreak in Korea.
- Authors
Shin, Saeam; Jeong, Seok Hoon; Lee, Hyukmin; Hong, Jun Sung; Park, Min-Jeong; Song, Wonkeun
- Abstract
Background: Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant <italic>Providencia rettgeri</italic> from January 2016 to January 2017 at a University Hospital in Seoul, Korea. Methods: A total of eight non-duplicate <italic>P. rettgeri</italic> isolates were discovered from urine samples from eight patients having a urinary catheter and admitted in a surgical intensive care unit. The β-lactamase genes were identified using polymerase chain reaction and direct sequencing, and strain typing was done with pulsed-field gel electrophoresis (PFGE). Results: All isolates showed high-level resistance to extended-spectrum cephalosporins, aztreonam, meropenem, ertapenem, ciprofloxacin, and amikacin. They harbored the <italic>bla</italic>NDM-1 carbapenemase and the <italic>bla</italic>PER-1 type extended-spectrum β-lactamases genes. PFGE revealed that all isolates from eight patients were closely related strains. Conclusions: The 13-month outbreak ended following reinforcement of infection control measures, including contact isolation precautions and environmental disinfection. This is the first report of an outbreak of a <italic>P. rettgeri</italic> clinical isolates co-producing NDM-1 and PER-1 β-lactamase.
- Subjects
ENTEROBACTERIACEAE diseases; MULTIDRUG resistance in bacteria; CARBAPENEMASE; URINARY tract infections; BETA lactamases
- Publication
Annals of Clinical Microbiology & Antimicrobials, 2018, Vol 17, Issue 1, pN.PAG
- ISSN
1476-0711
- Publication type
Article
- DOI
10.1186/s12941-018-0272-y